Sunday, July 18, 2010

Syphilis

Syphilis:
A sexually transmitted disease caused by Treponema pallidum.

Syphilis is a major health problem. About 12 million new cases of syphilis occur every year. More than 90% of them are in developing nations where congenital syphilis remains a leading cause of stillbirths and newborn deaths. In North America and Western Europe, syphilis is disproportionately common and rising among men who have sex with men and among persons who use cocaine or other illicit drugs.


There are three stages of syphilis:

  • The first (primary) stage (1-5 weeks): This involves the formation of the chancre,a classic painless ulcer of syphilis. At this stage, syphilis is highly contagious.
  • The second (secondary) stage (4-6 weeks): However, 25 percent of cases will proceed to the secondary stage of syphilis.
This phase can include hair loss; a sore throat; white patches in the nose, mouth, and vagina; fever; headaches; and a skin rash. There can be lesions on the genitals that look like genital warts, but are caused by spirochetes rather than the wart virus. These wart-like lesions, as well as the skin rash, are highly contagious. The rash can occur on the palms of the hands, and the infection can be transmitted by casual contact.
  • The third (tertiary) stage: This final stage of the disease involves the brain and heart, and is usually no longer contagious. At this point, however, the infection can cause extensive damage to the internal organs and the brain, and can lead to death.
Diagnosis :
Is by following blood tests
  • Rapid plasma reagin (RPR)
  • Venereal Disease Research Laboratory (VDRL) test.
  • Fluorescent treponemal antibody absorbed (FTA-ABS) test.
Treatment :
Syphilis is treated with penicillin, administered by injection.

Other antibiotics can be used for patients allergic to penicillin.
A small percentage of patients do not respond to the usual doses of penicillin. Therefore, it is important that patients have periodic repeat blood tests to make sure that the infectious agent has been completely destroyed and there is no further evidence of the disease.
In all stages of syphilis, proper treatment will cure the disease, but in late syphilis, damage already done to body organs cannot be reversed.

Prevention of Syphilis:
Patients with infectious syphilis should abstain from sexual activity until rendered noninfectious by antibiotic therapy.
Talk openly with your partner about STDs, HIV, and hepatitis B infection, and the use of contraception. All sexually active persons should consider using latex condoms to prevent STDs and HIV infection, even if they are using another form of contraception.
Latex condoms used consistently and correctly are an effective means for preventing disease (and pregnancy). Since latent condoms protect covered parts only, the exposed parts should be washed with soap and water as soon after contact as possible. This applies to men and women.


Mouth ulcers

What are Mouth Ulcers?

Mouth ulcers are small oval sores, red in colour, which develop inside the mouth. They are commonly found in the inner part of the cheeks, inside the lips, under the tongue or on the soft palate. This type of ulcer is not contagious unlike cold sores and usually disappears after a couple of weeks.

These are also known as ‘canker sores’ or ‘aphthous ulcers’.

Mouth ulcers affect both men and women although women are more commonly affected. Teenagers are especially prone to developing these which can often be a result of stress, poor diet or a lack of sleep!

You may find that you develop mouth ulcers if you are ‘run down’ or have high stress levels.

What does a mouth ulcer look like?

It is a round or oval type of swelling with a yellow or white coloured centre. It may have a ‘crater-like’ appearance and is often red and painful. Most people experience a single mouth ulcer but it is not uncommon to develop several ulcers at once.

You may experience pain when you eat or drink anything hot or cold. For those suffering with chronic mouth ulcers, they can expect to see as many 15 or 20 at a time.

Types of mouth ulcers

There are three types of mouth ulcers which are as follows:

  • Minor ulcers
  • Major ulcers
  • Herpetiform ulcers

Minor ulcers

Around 80% of all mouth ulcers are the minor type. They are oval or round in shape and are no bigger than 10mm in size. They have a pale yellow colour but often look red and swollen although they are not usually painful.

Usually just the one ulcer appears but up to five can appear at the same time.

This type of ulcer lasts for a week to ten days and disappears without any scarring.

Major ulcers

This type of ulcer is bigger and deeper than a minor ulcer and tends to occur in about 1 out of 10 cases. Usually one ulcer develops although two can appear at the same time. This ulcer lasts from ten days to several months but in some cases, they can remain for a year or two. These painful ulcers leave a scar after they have disappeared.

Herpetiform ulcers

Also known as ‘pinpoint’ulcers: these tiny ulcers are no bigger than 3mm in size and appear as clusters. These clusters can contain from four or five ulcers up to 100. In some cases they can combine together to form large, irregular shaped groups of ulcers.

This type of ulcer appears in 10% of cases.

They usually take a week to ten days to clear and don’t result in any scarring.

Mouth ulcers are more common in people aged between 10 and 40. After that they tend to appear on occasions but this is less likely over time. Basically the older you get the less chance you have of developing mouth ulcers.

At some point you may stop developing mouth ulcers altogether.

Are mouth ulcers contagious?

No. You cannot get mouth ulcers from kissing or sharing a glass which has been used by someone with a mouth ulcer.

But what are contagious are cold sores which are formed from the herpes virus and can be transmitted via personal contact, e.g. kissing.

Some people rarely develop mouth ulcers but there are others who suffer from these on a regular basis. Around 1 in five people experience ‘recurring’mouth ulcers which can be a miserable experience.

If you are one of these unlucky sufferers then find out more in our persistent mouth ulcers section.


DIARRHOEA

DIARRHOEA

What is diarrhoea?

Diarrhoea is loose, watery stools occurring more than three times in one day. Diarrhoea is a common problem that usually lasts a day or two and goes away on its own without any special treatment. However, prolonged diarrhoea can be a sign of other problems. People with diarrhoea may pass more than a quart of stool a day.

Diarrhoea can cause dehydration, which means the body lacks enough fluid to function properly. Dehydration is particularly dangerous in children and the elderly, and it must be treated promptly to avoid serious health problems.

People of all ages can get diarrhoea. The average adult has a bout of diarrhoea about four times a year.

What causes diarrhoea?

Diarrhoea may be caused by a temporary problem, like an infection, or a chronic problem, like an intestinal disease. A few of the more common causes of diarrhoea are

  • Bacterial infections. Several types of bacteria, consumed through contaminated food or water, can cause diarrhoea. Common culprits include Campylobacter, Salmonella, Shigella, and Escherichia coli.

  • Viral infections. Many viruses cause diarrhoea, including rotavirus, Norwalk virus, cytomegalovirus, herpes simplex virus, and viral hepatitis.

  • Food intolerances. Some people are unable to digest some component of food, such as lactose, the sugar found in milk.

  • Parasites. Parasites can enter the body through food or water and settle in the digestive system. Parasites that cause diarrhoea include Giardia lamblia, Entamoeba histolytica, and Cryptosporidium.

  • Reaction to medicines, such as antibiotics, blood pressure medications, and antacids containing magnesium.

  • Intestinal diseases, like inflammatory bowel disease or coeliac disease.

  • Functional bowel disorders, such as irritable bowel syndrome, in which the intestines do not work normally.

Some people develop diarrhoea after stomach surgery or removal of the gallbladder. The reason may be a change in how quickly food moves through the digestive system after stomach surgery or an increase in bile in the colon that can occur after gallbladder surgery.

In many cases, the cause of diarrhoea cannot be found. As long as diarrhoea goes away on its own, an extensive search for the cause is not usually necessary.

People who visit foreign countries are at risk for traveller's diarrhoea, which is caused by eating food or drinking water contaminated with bacteria, viruses, or, sometimes, parasites. Traveller's diarrhoea is a particular problem for people visiting developing countries. Visitors to the United States, Canada, most European countries, Japan, Australia, and New Zealand do not face much risk for traveller's diarrhoea. (See "Preventing Traveller's Diarrhoea" below)

What are the symptoms?

Diarrhoea may be accompanied by cramping abdominal pain, bloating, nausea, or an urgent need to use the bathroom. Depending on the cause, a person may have a fever or bloody stools.

Diarrhoea can be either acute (short-term) or chronic (long-term). The acute form, which lasts less than 4 weeks, is usually related to a bacterial, viral, or parasitic infection. Chronic diarrhoea lasts more than 4 weeks and is usually related to functional disorders like irritable bowel syndrome or inflammatory bowel diseases like coeliac disease.

Diarrhoea in Children

Children can have acute or chronic forms of diarrhoea. Causes include bacteria, viruses, parasites, medications, functional disorders, and food sensitivities. Infection with the rotavirus is the most common cause of acute childhood diarrhoea. Rotavirus diarrhoea usually resolves in 3 to 9 days.

Medications to treat diarrhoea in adults can be dangerous to children and should be given only under a doctor's guidance.

Diarrhoea can be dangerous in newborns and infants. In small children, severe diarrhoea lasting just a day or two can lead to dehydration. Because a child can die from dehydration within a few days, the main treatment for diarrhoea in children is rehydration. (See "Preventing Dehydration" below .)


What is dehydration?

General signs of dehydration include

  • thirst
  • less frequent urination
  • dry skin
  • fatigue
  • light-headedness
  • dark colored urine

Signs of dehydration in children include

  • dry mouth and tongue
  • no tears when crying
  • no wet nappies (diapers) for 3 hours or more
  • sunken abdomen, eyes, or cheeks
  • high fever
  • listlessness or irritability
  • skin that does not flatten when pinched and released

If you suspect that you or your child is dehydrated, call the doctor immediately. Severe dehydration may require hospitalization.

When should a doctor be consulted?

Although usually not harmful, diarrhoea can become dangerous or signal a more serious problem. You should see the doctor if any of the following is true:

  • You have diarrhoea for more than 3 days.
  • You have severe pain in the abdomen or rectum.
  • You have a fever of 102 degrees Fahrenheit or higher.
  • You see blood in your stool or have black, tarry stools.
  • You have signs of dehydration.

If your child has diarrhoea, do not hesitate to call the doctor for advice. Diarrhoea can be dangerous in children if too much fluid is lost and not replaced quickly.

What tests might the doctor do?

Diagnostic tests to find the cause of diarrhoea include the following:

  • Medical history and physical examination. The doctor will need to know about your eating habits and medication use and will examine you for signs of illness.

  • Stool culture. Lab technicians analyze a sample of stool to check for bacteria, parasites, or other signs of disease or infection.

  • Blood tests. Blood tests can be helpful in ruling out certain diseases.

  • Fasting tests. To find out if a food intolerance or allergy is causing the diarrhoea, the doctor may ask you to avoid lactose (found in milk products), carbohydrates, wheat, or other foods to see whether the diarrhoea responds to a change in diet.

  • Sigmoidoscopy. For this test, the doctor uses a special instrument to look at the inside of the rectum and lower part of the colon.

  • Colonoscopy. This test is similar to sigmoidoscopy, but the doctor looks at the entire colon.
What is the treatment?

In most cases, replacing lost fluid to prevent dehydration is the only treatment necessary. (See "Preventing Dehydration" below.) Medicines that stop diarrhoea may be helpful in some cases, but they are not recommended for people whose diarrhoea is caused by a bacterial infection or parasite - stopping the diarrhoea traps the organism in the intestines, prolonging the problem. Instead, doctors usually prescribe antibiotics. Viral causes are either treated with medication or left to run their course, depending on the severity and type of the virus.

Preventing Dehydration

Dehydration occurs when the body has lost too much fluid and electrolytes (the salts potassium and sodium). The fluid and electrolytes lost during diarrhoea need to be replaced promptly - the body cannot function properly without them. Dehydration is particularly dangerous for children, who can die from it within a matter of days.

Although water is extremely important in preventing dehydration, it does not contain electrolytes. To maintain electrolyte levels, you could have broth or soups, which contain sodium, and fruit juices, soft fruits, or vegetables, which contain potassium.

For children, doctors often recommend a special rehydration solution that contains the nutrients they need. You can buy this solution in the grocery store without a prescription. Examples include Pedialyte, Ceralyte, and Infalyte.

Tips About Food

Until diarrhoea subsides, try to avoid milk products and foods that are greasy, high-fiber, or very sweet. These foods tend to aggravate diarrhoea.

As you improve, you can add soft, bland foods to your diet, including bananas, plain rice, boiled potatoes, toast, crackers, cooked carrots, and baked chicken without the skin or fat. For children, the paediatrician may recommend what is called the BRAT diet: bananas, rice, applesauce, and toast.

Preventing Traveller's Diarrhoea

Traveller's diarrhoea happens when you consume food or water contaminated with bacteria, viruses, or parasites. You can take the following precautions to prevent traveller's diarrhoea when you go abroad:

  • Do not drink any tap water, not even when brushing your teeth.

  • Do not drink unpasteurized milk or dairy products.

  • Do not use ice made from tap water.

  • Avoid all raw fruits and vegetables (including lettuce and fruit salad) unless they can be peeled and you peel them yourself.

  • Do not eat raw or rare meat and fish.

  • Do not eat meat or shellfish that is not hot when served to you.

  • Do not eat food from street vendors.
You can safely drink bottled water (if you are the one to break the seal), carbonated soft drinks, and hot drinks like coffee or tea.

Depending on where you are going and how long you are staying, your doctor may recommend that you take antibiotics before leaving to protect you from possible infection.

Points to Remember
  • Diarrhoea is a common problem that usually resolves on its own.

  • Diarrhoea is dangerous if a person becomes dehydrated.

  • Causes include viral, bacterial, or parasitic infections; food intolerance; reactions to medicine; intestinal diseases; and functional bowel disorders.

  • Treatment involves replacing lost fluids and electrolytes. Depending on the cause of the problem, a person might also need medication to stop the diarrhoea or treat an infection. Children may need an oral rehydration solution to replace lost fluids and electrolytes.

  • Call the doctor if a person with diarrhoea has severe pain in the abdomen or rectum, a fever of 102 degrees Fahrenheit or higher, blood in the stool, signs of dehydration, or diarrhoea for more than 3 days.

Rickets

Rickets

Osteomalacia in children; Vitamin D deficiency; Renal rickets; Hepatic rickets

Last reviewed: August 3, 2010.

Rickets is a disorder caused by a lack of vitamin D, calcium, or phosphate. It leads to softening and weakening of the bones.

Causes, incidence, and risk factors

Vitamin D helps the body control calcium and phosphate levels. If the blood levels of these minerals become too low, the body may produce hormones that cause calcium and phosphate to be released from the bones. This leads to weak and soft bones.

Vitamin D is absorbed from food or produced by the skin when exposed to sunlight. Lack of vitamin D production by the skin may occur in people who:

  • Live in climates with little exposure to sunlight

  • Must stay indoors

  • Work indoors during the daylight hours

You may not get enough vitamin D from your diet if you:

  • Are lactose intolerant (have trouble digesting milk products)

  • Do not drink milk products

  • Follow a vegetarian diet

Infants who are breastfed only may develop vitamin D deficiency. Human breast milk does not supply the proper amount of vitamin D. This can be a particular problem for darker-skinned children in winter months (when there are lower levels of sunlight).

Not getting enough calcium and phosphorous in your diet can also lead to rickets. Rickets caused by a lack of these minerals in diet is rare in developed countries, because calcium and phosphorous are found in milk and green vegetables.

Your genes may increase your risk of rickets. Hereditary rickets is a form of the disease that is passed down through families. It occurs when the kidneys are unable to hold onto the mineral phosphate. Rickets may also be caused by kidney disorders that involve renal tubular acidosis.

Disorders that reduce the digestion or absorption of fats will make it more difficult for vitamin D to be absorbed into the body.

Occasionally, rickets may occur in children who have disorders of the liver, or who cannot convert vitamin D to its active form.

Rickets is rare in the United States. It is most likely to occur in children during periods of rapid growth, when the body needs high levels of calcium and phosphate. Rickets may be seen in children ages 6 - 24 months. It is uncommon in newborns.

Symptoms

  • Bone pain or tenderness

    • Arms

    • Legs

    • Pelvis

    • Spine

  • Dental deformities

    • Delayed formation of teeth

    • Decreased muscle tone (loss of muscle strength)

    • Defects in the structure of teeth; holes in the enamel

    • Increased cavities in the teeth (dental caries)

    • Progressive weakness

  • Impaired growth

  • Increased bone fractures

  • Muscle cramps

  • Short stature (adults less than 5 feet tall)

  • Skeletal deformities

    • Asymmetrical or odd-shaped skull

    • Bowlegs

    • Bumps in the ribcage (rachitic rosary)

    • Breastbone pushed forward (pigeon chest)

    • Pelvic deformities

    • Spine deformities (spine curves abnormally, including scoliosis or kyphosis)

Signs and tests

A physical exam reveals tenderness or pain in the bones, rather than in the joints or muscles.

The following tests may help diagnose rickets:

  • Arterial blood gases

  • Blood tests (serum calcium)

  • Bone biopsy (rarely done)

  • Bone x-rays

  • Serum alkaline phosphatase

  • Serum phosphorus

Other tests and procedures include the following:

  • ALP (alkaline phosphatase) isoenzyme

  • Calcium (ionized)

  • PTH

  • Urine calcium

Treatment

The goals of treatment are to relieve symptoms and correct the cause of the condition. The cause must be treated to prevent the disease from returning.

Replacing calcium, phosphorus, or vitamin D that is lacking will eliminate most symptoms of rickets. Dietary sources of vitamin D include fish, liver, and processed milk. Exposure to moderate amounts of sunlight is encouraged. If rickets is caused by a metabolic problem, a prescription for vitamin D supplements may be needed.

Positioning or bracing may be used to reduce or prevent deformities. Some skeletal deformities may require corrective surgery.

Expectations (prognosis)

The disorder may be corrected by replacing vitamin D and minerals. Laboratory values and x-rays usually improve after about 1 week, although some cases may require large doses of minerals and vitamin D.

If rickets is not corrected while the child is still growing, skeletal deformities and short stature may be permanent. If it is corrected while the child is young, skeletal deformities often improve or disappear with time.

Complications

  • Chronic skeletal pain

  • Skeletal deformities

  • Skeletal fractures, may occur without cause

Calling your health care provider

Call your child's health care provider if you notice symptoms of rickets.

Prevention

You can prevent rickets by making sure that your child gets enough calcium, phosphorus, and vitamin D in the diet. People who have gastrointestinal or other disorders may need to take supplements. Ask your child's health care provider.

Kidney (renal) causes of poor vitamin D absorption should be treated right away. People who have renal disorders should have their calcium and phosphorus levels monitored regularly.

Genetic counseling may help people who have a family history of inherited disorders that can cause rickets.

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